Screening Procedure for Hemihypertrophy: Preliminary Results of International Multicenter Prospective Study

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Michael Vaiman
Phillip Shilco
Yulia Roitblat
Nicolas Padilla-Raygoza
Aidan Leit
Aaron Kavin
Edan Schonberger
Liliia Nehuliaieva
Noa Buchris
Michael Shterenshis


Introduction: Isolated or congenital hemihypertrophy is a rare disorder characterized by asymmetric overgrowth of one side of the body. This article describes the protocol and preliminary results of a lateral body asymmetry (hemihypertrophy) screening procedure performed in healthy adolescents in a multicenter study. The reported incidence of hemihypertrophy varies between different publications and standardized protocols are needed to improve research in this area.

Methods: Our screening program is taking place in Australia, Israel, Mexico, Ukraine and USA. Procedure includes two steps:  (1) “three measurements – three questions” screening, or assessment of face, palms, and shins; (2) in-depth assessment of selected cases in order to exclude localized, lesional, and syndrome-related cases as well as body asymmetry within normative range and to select suspected cases of isolated hemihypertrophy. This step includes measurements of various anatomical regions and a detailed questionnaire.

Results: At this stage, the screening procedure is completed and the selected participants are advised to refer to medical institutions for further clinical and genetic follow up to exclude possible tumors and other accompanying disorders.

Conclusion: We present an easy-to-use selection tool to identify children with suspected IH, which results in the selection of the risk group that may benefit from referral to a pediatrician and a clinical geneticist.

Article Details

How to Cite
Vaiman, M., Shilco, P., Roitblat, Y., Padilla-Raygoza, N., Leit, A., Kavin, A., Schonberger, E., Nehuliaieva, L., Buchris, N., & Shterenshis, M. (2019). Screening Procedure for Hemihypertrophy: Preliminary Results of International Multicenter Prospective Study. Central Asian Journal of Global Health, 8(1).
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Author Biographies

Michael Vaiman, Department of Otolaryngology, Assaf Harofeh Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel


Nicolas Padilla-Raygoza, Department of Nursing and Obstetrics, Division of Health Sciences and Engineering, Campus Celaya-Salvatierra, University of Guanajuato, Mexico

professor, Department of Nursing and Obstetrics

Aidan Leit, Department of Sciences, The Harley School, Rochester, NY, USA

Department of Sciences

Aaron Kavin, Department of Anatomy, Mount Moriah College, Sydney, Australia

Department of Anatomy

Liliia Nehuliaieva, Department of Pediatrics, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine

Department of Pediatrics

Michael Shterenshis, Science Research Department, Alexander Muss High School in Israel (AMHSI) affiliated with Alexander Muss Institute for Israel Education (AMIIE), Hod HaSharon, Israel

Head of Science Research Department, AMHSI


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