Hydatid Disease in the Central Region of Iran: A 5-year Epidemiological and Clinical Overview

Main Article Content

Aliasghar Farazi
Nader Zarinfar
Farhad Kayhani
Firoozeh Khazaie

Abstract

Introduction: Hydatid cyst is caused by an infection by the larval stage of Echinococcus granulosus. Patients with cystic echinococcosis often remain asymptomatic until the hydatid cysts grow large enough to cause symptoms and signs. The cysts grow in the course of several years before reaching maturity and the rate of growth depends on the location of the cyst.

Methods: This study was conducted in the Central region of Iran and involved all patients diagnosed with hydatid disease from 2012 to 2016 with the records identifed from 10 centers for disease control. Descriptive statistics including range and percentage were used in analyzing the patient characteristics.

Results: Hydatid disease was confirmed in 84 cases. The mean age of patients was (23.1±5.1) years (range: 15-53 years) and 55.9% of cases were female. Single organ involvement was found in 86.9% of cases. 98.8% cases were successfully treated. The most common sites of infection were lung (42.9%), followed by liver (38.1%), and joint liver/lung (10.7%). The diagnosis was established by abdominal ultrasound, abdominal CT, and serology in all patients. The diagnosis was confirmed by histology in 80 (95.2%) of cases. All of cases were treated with albendazole, and 80 (95.2%) of cases had surgical intervention. The prevalence of human hydatidosis in our study was 1.16 per 100,000 population.

Conclusions: Hydatid disease is common in Iran and should be a focus of public health interventions. The organ sites affected in this study include lung and liver.

Article Details

How to Cite
Farazi, A., Zarinfar, N., Kayhani, F., & Khazaie, F. (2019). Hydatid Disease in the Central Region of Iran: A 5-year Epidemiological and Clinical Overview. Central Asian Journal of Global Health, 8(1). https://doi.org/10.5195/cajgh.2019.364
Section
Short Reports

References

Ravis E, Theron A, Lecomte B, Gariboldi V. Pulmonary cyst embolism: a rare complication of hydatidosis. Eur J Cardiothorac Surg. 2018 Jan 1. 53 (1):286-7.

Meeting of the WHO Informal Working Group on Echinococcosis (WHO-IWGE), Geneva, Switzerland, 15–16 December 2016. Geneva, Switzerland: World Health Organization; 2017 (WHO/HTM/ NTD/NZD/2017.01). License: CC BY-NC-SA 3.0 IGO.

Siracusano A, Delunardo F, Teggi A, Ortona E. Host-parasite relationship in cystic echinococcosis: an evolving story. Clin Dev Immunol. 2012. 2012:639362.

Wang K, Zhang X, Jin Z, Ma H, Teng Z, Wang L. Modelling and analysis of the transmission of echinococcosis with application to Xinjiang Uygur Autonomous Region of China. J Theor Biol. 2013 May 10.

Torgerson PR. The emergence of echinococcosis in central Asia. Parasitology. 2013 May 10. 1-7.

Ito A, Budke CM. The echinococcoses in Asia: the present situation. Acta Trop. 2017 Dec. 176:11-21.

Moldovan R, Neghina AM, Calma CL, Marincu I, Neghina R. Human cystic echinococcosis in two south-western and central-western Romanian counties: A 7-year epidemiological and clinical overview. Acta Trop. 2012 Jan. 121(1):26-9.

Manterola C, Otzen T, Munoz G, Alanis M, Kruuse E, Figueroa G. Surgery for hepatic hidatidosis. Risk factors and variables associated with postoperative morbidity. Overview of the existing evidence. Cir Esp. 2017 Dec. 95 (10):566-76.

Ahmadi NA, Badi F. Human hydatidosis in Tehran, Iran: a retrospective epidemiological study of surgical cases between 1999 and 2009 at two university medical centers. Trop Biomed 2011; 28: 450-456.

Yang YR, Rosenzvit MC, Zhang LH, Zhang JZ, McManus DP. Molecular study of Echinococcus in west-central China. Parasitology 2005; 131: 547-555.

Sako Y, Nakao M, Nakaya K, Yamasaki H, Ito A. Recombinant antigens for sero diagnosis of cysticercosis and echinococcosis. Parasitol Int 2006; 55(Suppl): S69-S73.

Sadjjadi SM. Present situation of echinococcosis in the Middle East and Arabic North Africa. Parasitol Int. 2006; 55 Suppl: S197-202.

Rokni MB. The present status of human helminthic diseases in Iran. Ann Trop Med Parasitol. 2008; 102(4):283-295.

Montazeri, V, Sokouti M, Rashidi H. Comparison of pulmonary hydatid disease between children and adult. Tanaffos. 2007; 6(1):13- 18.

Priego P, Nuño J, López Hervás P, López Buenadicha A, Peromingo R, Díe J, et al. Hepatic hydatidosis. Radical vs. conservative surgery: 22 years of experience. Revista Espanola de Enfermedades Digestivas. 2008; 100(2):82-5.

Rokni M. Echinococcosis/hydatidosis in Iran. Iranian J Parasitol, 2009; 4(2):1-16.

Shambesh MA, Craig PS, Macpherson CN, Rogan MT, Gusbi AM, Echtuish EF. An extensive ultrasound and serologic study to investigate the prevalence of human cystic echinococcosis in northern Libya. The American journal of tropical medicine and hygiene. 1999; 60(3):462-8.

Al-Shibani L. Cases of hydatidosis in patients referred to Governmental hospitals for cyst removal in Sana’a City, Republic of Yemen. Trop Biomed, 2012; 29(1):18r23.

Alghoury A, El-Hamshary E, Azazy A, Hussein E, Rayan HZ. Hydatid disease in Yemeni patients attending public and private hospitals in Sana’a city, Yemen. Oman medical journal. 2010; 25(2):88.

Sarkari B, Sadjjadi S, Beheshtian M, Aghaee M, Sedaghat F. Human cystic Echinococcosis in Yasuj district in Southwest of Iran: an epidemiological study of seroprevalence and surgical cases over a ten‐year period. Zoonoses and public health. 2010; 57(2):146-50.

Harandi MF, Budke CM, Rostami S. The monetary burden of cystic echinococcosis in Iran. PLOS neglected tropical diseases. 2012;6(11):1915

Mousavi S, Samsami M, Fallah M, Zirakzadeh H. A retrospective survey of human hydatidosis based on hospital records during the period of 10 years. Journal of Parasitic Diseases. 2012;36(1):7-9.