The HUPO Human Proteome Project (HPP), a Global Health Research Collaboration

Gilbert S. Omenn


The global Human Proteome Project (HPP) was announced by the Human Proteome Organization (HUPO) at the 2010 World Congress of Proteomics in Sydney, Australia, and launched at the 2011 World Congress of Proteomics in Geneva, Switzerland, with analogies to the highly successful Human Genome Project. Extensive progress was reported at the September 2012 World Congress in Boston, USA. The HPP is designed to map the entire human proteome using available and emerging technologies.

The HPP aims to create a molecular and biological foundation for improving health globally through better understanding of disease processes, more accurate diagnoses, and targets for more effective therapies and preventive interventions against many diseases. There are opportunities for individual investigators everywhere to access advanced datasets and to join HPP research teams.

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Omenn GS. The new life sciences: Understanding the essentials of life. A keynote address at the Bibliotheca Alexandrina. BioVision 2012 (in press).

Legrain P, Aebersold R, Archakov A, Bairoch A, Bala K, Beretta L, et al. The human proteome project: current state and future direction. Mol Cell Proteomics. 2011 Jul;10(7): M111.009993. doi: 10.1074/ mcp.M111.009993-1

Laporte RE, Omenn GS, Serageldin I, Cerf VG, Linkov F. A Scientific Supercourse. Science. 2006;312(5773):526. doi:10.1126/science.312.5773.526c

Uhlen M, Oksvold P, Älgenäs C, Hamsten C, Fagerberg L, Klevebring D, et al. Antibody-based protein profiling of the human chromosome 21. Mol Cell Proteomics. 2012 Mar;11(3): M111.013458. doi: 10.1074/mcp.M111.013458

Farrah T, Deutsch EW, Omenn GS, Campbell DS, Sun Z, Bletz JA, et al. A high-confidence human plasma proteome reference set with estimated concentrations in peptideatlas. Mol Cell Proteomics. 2011 Sep; 10(9):M110.006353. doi: 10.1074/mcp.M110.006353

Paik YK, Jeong SK, Omenn GS, Uhlen M, Hanash S, Cho SY, et al. The chromosome-centric Human Proteome Project for cataloging proteins encoded in the genome. Nat Biotechnol. 2012 Mar 7;30(3):221-223. doi: 10.1038/nbt.2152

Paik YK, Omenn GS, Uhlen M, Hanash S, Marko-Varga G, Aebersold R, et al. Standard guidelines for the chromosome-centric Human Proteome Project. J Proteome Res. 2012 Apr 6;11(4):2005-2013. doi: 10.1021/pr200824a



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