Detection of Hepatitis E Antibodies in Kazakhstan: A Pilot Study

Francesca Cainelli, Gonzalo Hortelano, Baurzhan Negmetzhanov, Aigerim Ibrayeva, Kulpash Kaliaskarova, Denis Bulanin, Sandro Vento

Abstract


Introduction. Hepatitis E virus exposure is associated with sporadic cases of acute hepatitis and outbreaks in many countries worldwide. It is particularly dangerous for pregnant women, in whom the mortality rate is high. There are no previously published data reporting circulation of this virus in Kazakhstan.

Methods. We tested blood samples for IgG anti-hepatitis E virus antibodies in 199 Kazakh participants; of  these 119 were workers at the EXPO 2017 building site in Astana, 35 were volunteers who got tested at the Astana City Hall on the World Hepatitis Day 2017, and 45 were volunteers who presented for screening at the Hepatogastroenterology Outpatient Clinic of the Republican Diagnostic Center, University Medical Center.

Results. 11 (5.5%) individuals were positive for IgG anti-HEV antibodies, with a higher seroprevalence in males (7; 6.8%) vs females (4; 4.5%). The highest number of positive samples was in the 32-46 years age group.

Conclusions. This pilot study suggests that Hepatitis E virus has been circulating in Kazakhstan. Studies are needed to determine whether it continues to be present, which viral genotypes are involved and what are the best methodologies for preventing its spread.


Keywords


Hepatitis E; anti-HEV antibodies; Kazakhstan

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References


Khuroo MS. Study of an epidemic of non-A, non-B hepatitis. Possibility of another human hepatitis virus distinct from post-transfusion non-A, non-B type. Am J Med. 1980 Jun;68(6):818-24.

Tam AW, Smith MM, Guerra ME, et al. Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome. Virology. 1991 Nov;185(1):120-31.

Purcell RH, Emerson SU. Hepatitis E: an emerging awareness of an old disease. J Hepatol. 2008 Mar;48(3):494-503. doi: 10.1016/j.jhep.2007.12.008.

Rein DB, Stevens GA, Theaker J, Wittenborn JS, Wiersma ST. The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology. 2012 Apr;55(4):988-97. doi: 10.1002/hep.25505.

Kamar N, Bendall R, Legrand-Abravanel F, et al. Hepatitis E. Lancet. 2012 Jun 30;379(9835):2477-88. doi: 10.1016/S0140-6736(11)61849-7.

Ranjan A, Thakur S, Mokta J, Bhawani R, Ranjan V. Clinical profile and outcome of pregnant patients with acute HEV hepatitis during water borne epidemic in Himachal Pradesh: A hospital based study. J Assoc Physicians India. 2017 Dec;65(12):44-48.

Javed N, Ullah SH, Hussain N, et al. Hepatitis E virus seroprevalence in pregnant women in Pakistan: maternal and fetal outcomes. East Mediterr Health J. 2017 Oct 30;23(8):559-563.

Patra S, Kumar A, Trivedi SS, Puri M, Sarin SK. Maternal and fetal outcomes in pregnant women with acute hepatitis E virus infection. Ann Intern Med. 2007 Jul 3;147(1):28-33.

Teo CG. Much meat, much malady: changing perceptions of the epidemiology of hepatitis E. Clin Microbiol Infect. 2010 Jan;16(1):24-32. doi: 10.1111/j.1469-0691.2009.03111.x.

Murali AR, Kotwal V, Chawla S. Chronic hepatitis E: A brief review. World J Hepatol. 2015; 7(19): 2194-2201. doi: http://dx.doi.org/10.4254/wjh.v7.i19.2194.

Kamar N, Bendall RP, Peron JM, et al. Hepatitis E virus and neurologic disorders. Emerg Infect Dis. 2011 Feb;17(2):173-9. doi: 10.3201/eid1702.100856.

Usmanov RK, Favorov MO, Vasil'eva VI, et al. A comparative study of enteral hepatitis E (non-A, non-B) in the valley and mountainous areas of Kirghizia [in Russian]. Vopr Virusol. 1991 Jan-Feb;36(1):66-9.

Sharapov MB, Favorov MO, Yashina TL, et al. Acute viral hepatitis morbidity and mortality associated with hepatitis E virus infection: Uzbekistan surveillance data. BMC Infect Dis. 2009 Mar 25; 9: 35. doi: 10.1186/1471-2334-9-35.

Albetkova A, Drobeniuc J, Yashina T, et al. Characterization of hepatitis E virus from outbreak and sporadic cases in Turkmenistan. J Med Virol. 2007 Nov; 79(11): 1696-702. doi: 10.1002/jmv.20991.

Zhumatov Kh Zh, Dardik FG. Epidemic hepatitis in pregnancy [in Russian]. Akush Ginekol (Mosk). 1958 Nov-Dec; 34(6): 26-32.




DOI: https://doi.org/10.5195/cajgh.2018.324

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Copyright (c) 2018 Francesca Cainelli, Gonzalo Hortelano, Baurzhan Negmetzhanov, Aigerim Ibrayeva, Kulpash Kaliaskarova, Denis Bulanin, Sandro Vento

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